Peyronie’s disease is a condition in which a man’s penis becomes curved when erect. Peyronie’s disease involves extreme curvature that may make sex impossible. Get in shape fast, eat clean & lose weight, drink 100 oz of water a day, stop bad habits . Lack of response to oral ED medications or losing your erections before you and/or your partner are satisfied may indicate profound and severe blood vessel disease to the penis or leakage of blood out of penis during erection. Early onset erectile dysfunction is an early sign of worrisome heart disease, impending heart attack, even sudden death. If you experience a frequent and urgent need to urinate, suffer from a weak or slow stream and have a hard time emptying your bladder, it could be due to an enlarged prostate, otherwise known as benign prostatic hyperplasia.